I've always had trouble dragging myself out of bed. I've mentioned here that I have sleep problems and the early morning is the worst time for my motivation.
I take my Cymbalta once per it after I get up it. It's therefore at its lowest concentration in my system when I'm getting up. Since it has an "uplifting" effect I figured maybe it would make more sense to take it just before I go to bed so it will still have a fairly high concentration when I got up. The actual result was that it made me jittery at night and had trouble getting to sleep and staying asleep. I switched back to mornings pretty quickly.
I had run out yesterday but had a new prescription ready to be picked up. I grabbed it in the evening and took it as soon as I got home. It wasn't until about 7:00am that I realized why I couldn't sleep. My day was pretty much wasted for lack of ability to concentrate. I think I would have been better off not taking it yesterday.